| SEB CONCEPT BIOTECHNOLOGY - D EUR DIS | LU0118405827 | SEB Investment Management AB | 7,94% |
| UBS (LUX) EQUITY FUND-BIOTECH(USD) - P ACC | LU0069152568 | UBS Fund Management (Luxembourg) S.A. | 7,76% |
| UBS (LUX) EQUITY FUND-BIOTECH(USD) - Q ACC | LU0400035332 | UBS Fund Management (Luxembourg) S.A. | 7,76% |
| ALLIANZ BIOTECHNOLOGIE - A EUR DIS | DE0008481862 | Allianz Global Investors GmbH | 7,65% |
| ALLIANZ BIOTECHNOLOGIE - R EUR DIS | DE000A2AMPU5 | Allianz Global Investors GmbH | 7,65% |
| FRANKLIN BIOTECHNOLOGY DISCOVERY FUND - A USD ACC | LU0109394709 | Franklin Templeton International Services S.à r.l. | 6,40% |
| FRANKLIN BIOTECHNOLOGY DISCOVERY FUND - B USD ACC | LU0109394881 | Franklin Templeton International Services S.à r.l. | 6,40% |
| FRANKLIN BIOTECHNOLOGY DISCOVERY FUND - N USD ACC | LU0122613499 | Franklin Templeton International Services S.à r.l. | 6,40% |
| FRANKLIN BIOTECHNOLOGY DISCOVERY FUND - I USD ACC | LU0195948822 | Franklin Templeton International Services S.à r.l. | 6,40% |
| FRANKLIN BIOTECHNOLOGY DISCOVERY FUND - C USD ACC | LU0260873095 | Franklin Templeton International Services S.à r.l. | 6,40% |
| FRANKLIN BIOTECHNOLOGY DISCOVERY FUND - A SGD ACC | LU0320765992 | Franklin Templeton International Services S.à r.l. | 6,40% |
| FRANKLIN BIOTECHNOLOGY DISCOVERY FUND - Z GBP ACC | LU0774687577 | Franklin Templeton International Services S.à r.l. | 6,40% |
| FRANKLIN BIOTECHNOLOGY DISCOVERY FUND - I-H1 EUR ACC H | LU0889565759 | Franklin Templeton International Services S.à r.l. | 6,40% |
| FRANKLIN BIOTECHNOLOGY DISCOVERY FUND - A HKD ACC | LU0889565916 | Franklin Templeton International Services S.à r.l. | 6,40% |
| FRANKLIN BIOTECHNOLOGY DISCOVERY FUND - A-H1 CHF ACC H | LU0959058974 | Franklin Templeton International Services S.à r.l. | 6,40% |
| FRANKLIN BIOTECHNOLOGY DISCOVERY FUND - W USD ACC | LU0976566496 | Franklin Templeton International Services S.à r.l. | 6,40% |
| FRANKLIN BIOTECHNOLOGY DISCOVERY FUND - A-H1 EUR ACC H | LU1803069274 | Franklin Templeton International Services S.à r.l. | 6,40% |
| INVESCO MARKETS PLC-NASDAQ BIOTECH UCITS ETF - USD ACC | IE00BQ70R696 | Invesco Investment Management Limited | 6,27% |
| ISHARES NASDAQ US BIOTECHNOLOGY UCITS ETF - USD ACC | IE00BYXG2H39 | BlackRock Asset Management Ireland Limited | 6,27% |
| ISHARES NASDAQ US BIOTECHNOLOGY UCITS ETF - USD DIS | IE00BDZVHG35 | BlackRock Asset Management Ireland Limited | 6,27% |
| CANDRIAM EQUITIES L BIOTECHNOLOGY - C USD ACC | LU0108459040 | Candriam Luxembourg S.A. | 5,37% |
| CANDRIAM EQUITIES L BIOTECHNOLOGY - C USD DIS | LU0108459552 | Candriam Luxembourg S.A. | 5,37% |
| CANDRIAM EQUITIES L BIOTECHNOLOGY - I USD ACC | LU0133360163 | Candriam Luxembourg S.A. | 5,37% |
| CANDRIAM EQUITIES L BIOTECHNOLOGY - V USD ACC | LU0317020203 | Candriam Luxembourg S.A. | 5,37% |
| CANDRIAM EQUITIES L BIOTECHNOLOGY - R USD ACC | LU0942225912 | Candriam Luxembourg S.A. | 5,37% |
| CANDRIAM EQUITIES L BIOTECHNOLOGY - I EUR ACC H | LU1006082199 | Candriam Luxembourg S.A. | 5,37% |
| CANDRIAM EQUITIES L BIOTECHNOLOGY - C EUR ACC H | LU1120766206 | Candriam Luxembourg S.A. | 5,37% |
| CANDRIAM EQUITIES L BIOTECHNOLOGY - R EUR ACC H | LU1708110975 | Candriam Luxembourg S.A. | 5,37% |
| SB AKTIEN NORDAMERIKA - EUR DIS | AT0000A2C038 | Schoellerbank Invest AG | 5,07% |
| SB AKTIEN NORDAMERIKA - EUR ACC | AT0000A2C046 | Schoellerbank Invest AG | 5,07% |
| ERSTE STOCK BIOTEC - R01 EUR DIS | AT0000746748 | Erste Asset Management GmbH | 5,02% |
| ERSTE STOCK BIOTEC - R01 EUR ACC | AT0000746755 | Erste Asset Management GmbH | 5,02% |
| ERSTE STOCK BIOTEC - R01 EUR | AT0000673165 | Erste Asset Management GmbH | 5,02% |
| ERSTE STOCK BIOTEC - R01 CZK | AT0000A0XYP0 | Erste Asset Management GmbH | 5,02% |
| ERSTE STOCK BIOTEC - R01 HUF | AT0000A18XC5 | Erste Asset Management GmbH | 5,02% |
| ERSTE STOCK BIOTEC - D01 EUR DIS | AT0000A1YFC3 | Erste Asset Management GmbH | 5,02% |
| ERSTE STOCK BIOTEC - D01 EUR ACC | AT0000A1YFD1 | Erste Asset Management GmbH | 5,02% |
| ERSTE STOCK BIOTEC - D02 EUR | AT0000A1YFE9 | Erste Asset Management GmbH | 5,02% |
| ERSTE STOCK BIOTEC - D02 HUF | AT0000A1YFF6 | Erste Asset Management GmbH | 5,02% |
| ERSTE STOCK BIOTEC - D02 CZK | AT0000A1YFG4 | Erste Asset Management GmbH | 5,02% |
| ERSTE STOCK BIOTEC - I01 EUR DIS | AT0000A25NL2 | Erste Asset Management GmbH | 5,02% |
| ERSTE STOCK BIOTEC - I01 EUR | AT0000A26HX7 | Erste Asset Management GmbH | 5,02% |
| DEKALUX-BIOTECH - CF EUR DIS | LU0348461467 | Deka International S.A. | 4,71% |
| DEKALUX-BIOTECH - TF EUR DIS | LU0348461897 | Deka International S.A. | 4,71% |
| VARIOPARTNER SICAV SECTORAL BIOTECH OPPORTUNITIES FUND - I EUR ACC | LU1176837026 | Vontobel Asset Management S.A. | 4,54% |
| VARIOPARTNER SICAV SECTORAL BIOTECH OPPORTUNITIES FUND - P EUR ACC | LU1176838347 | Vontobel Asset Management S.A. | 4,54% |
| VARIOPARTNER SICAV SECTORAL BIOTECH OPPORTUNITIES FUND - I USD ACC | LU1176839154 | Vontobel Asset Management S.A. | 4,54% |
| VARIOPARTNER SICAV SECTORAL BIOTECH OPPORTUNITIES FUND - P USD ACC | LU1176840327 | Vontobel Asset Management S.A. | 4,54% |
| VARIOPARTNER SICAV SECTORAL BIOTECH OPPORTUNITIES FUND - Z USD ACC | LU1184014501 | Vontobel Asset Management S.A. | 4,54% |
| GAM MULTISTOCK - HEALTH INNOVATION EQUITY - A USD DIS | LU0329426521 | GAM (Luxembourg) S.A. | 4,51% |
| GAM MULTISTOCK - HEALTH INNOVATION EQUITY - B USD ACC | LU0329426950 | GAM (Luxembourg) S.A. | 4,51% |
| GAM MULTISTOCK - HEALTH INNOVATION EQUITY - C USD ACC | LU0329427255 | GAM (Luxembourg) S.A. | 4,51% |
| GAM MULTISTOCK - HEALTH INNOVATION EQUITY - BH EUR ACC H | LU0982197492 | GAM (Luxembourg) S.A. | 4,51% |
| DNB FUND - HEALTH CARE - A EUR ACC | LU1660425346 | DNB Asset Management S.A. | 4,47% |
| SCHOELLERBANK AKTIENFONDS DIVIDENDE - EUR DIS | AT0000A1KTN0 | Schoellerbank Invest AG | 4,20% |
| SCHOELLERBANK AKTIENFONDS DIVIDENDE - EUR ACC | AT0000A1KTP5 | Schoellerbank Invest AG | 4,20% |
| BELLEVUE FUNDS (LUX) BB ADAMANT BIOTECH - B EUR ACC | LU0415392249 | MDO Management Company S.A. | 4,01% |
| BELLEVUE FUNDS (LUX) BB ADAMANT BIOTECH - B USD ACC | LU0415392322 | MDO Management Company S.A. | 4,01% |
| BELLEVUE FUNDS (LUX) BB ADAMANT BIOTECH - B CHF ACC | LU0415392595 | MDO Management Company S.A. | 4,01% |
| BELLEVUE FUNDS (LUX) BB ADAMANT BIOTECH - I EUR ACC | LU0415392678 | MDO Management Company S.A. | 4,01% |
| BELLEVUE FUNDS (LUX) BB ADAMANT BIOTECH - I USD ACC | LU0415392751 | MDO Management Company S.A. | 4,01% |
| BELLEVUE FUNDS (LUX) BB ADAMANT BIOTECH - I CHF ACC | LU0415392835 | MDO Management Company S.A. | 4,01% |
| BELLEVUE FUNDS (LUX) BB ADAMANT BIOTECH - I GBP ACC | LU0767968745 | MDO Management Company S.A. | 4,01% |
| BELLEVUE FUNDS (LUX) BB ADAMANT BIOTECH - I2 EUR ACC | LU1725387622 | MDO Management Company S.A. | 4,01% |
| SCHOELLERBANK EQUITY INCOME - EUR ACC | AT0000A2B5E2 | Schoellerbank Invest AG | 3,84% |
| SCHOELLERBANK EQUITY INCOME - EUR DIS | AT0000A2B5D4 | Schoellerbank Invest AG | 3,84% |
| DWS INVEST CROCI SECTORS - ID AUD DIS | LU1769939528 | DWS Investment S.A. | 3,53% |
| DWS INVEST CROCI SECTORS - IC EUR ACC | LU1769939791 | DWS Investment S.A. | 3,53% |
| DWS INVEST CROCI SECTORS - ID EUR DIS | LU1769939874 | DWS Investment S.A. | 3,53% |
| DWS INVEST CROCI SECTORS - LC EUR ACC | LU1769940021 | DWS Investment S.A. | 3,53% |
| DWS INVEST CROCI SECTORS - LCH NOK ACC H | LU1769940294 | DWS Investment S.A. | 3,53% |
| DWS INVEST CROCI SECTORS - TFC EUR ACC | LU1769940377 | DWS Investment S.A. | 3,53% |
| DWS INVEST CROCI SECTORS - IC USD ACC | LU1769940450 | DWS Investment S.A. | 3,53% |
| DWS INVEST CROCI SECTORS - LC USD ACC | LU1769940534 | DWS Investment S.A. | 3,53% |
| DWS INVEST CROCI US DIVIDENDS - TFC EUR ACC | LU1769942407 | DWS Investment S.A. | 2,67% |
| DWS INVEST CROCI US DIVIDENDS - IC USD ACC | LU1769942589 | DWS Investment S.A. | 2,67% |
| DWS INVEST CROCI US DIVIDENDS - ID USD DIS | LU1769942662 | DWS Investment S.A. | 2,67% |
| DWS INVEST CROCI US DIVIDENDS - LC USD ACC | LU1769942746 | DWS Investment S.A. | 2,67% |
| DWS INVEST CROCI US DIVIDENDS - LD USD DIS | LU1769942829 | DWS Investment S.A. | 2,67% |
| DWS INVEST CROCI US DIVIDENDS - IC50 USD ACC | LU1949850454 | DWS Investment S.A. | 2,67% |
| MEDICAL BIOHEALTH - EUR DIS | LU0119891520 | Hauck & Aufhäuser Fund Services S.A. | 2,44% |
| MEDICAL BIOHEALTH - EUR DIS H | LU0228344361 | Hauck & Aufhäuser Fund Services S.A. | 2,44% |
| MEDICAL BIOHEALTH - I EUR DIS | LU0294851513 | Hauck & Aufhäuser Fund Services S.A. | 2,44% |
| MEDICAL BIOHEALTH - S EUR DIS H | LU0295354772 | Hauck & Aufhäuser Fund Services S.A. | 2,44% |
| MEDICAL BIOHEALTH - IX EUR DIS | LU1152054125 | Hauck & Aufhäuser Fund Services S.A. | 2,44% |
| MEDICAL BIOHEALTH - E EUR DIS | LU1783158469 | Hauck & Aufhäuser Fund Services S.A. | 2,44% |
| UNI-GLOBAL EQUITIES WORLD - SA USD ACC | LU0337270119 | Lemanik Asset Management S.A. | 2,18% |
| UNI-GLOBAL EQUITIES WORLD - SAH EUR ACC H | LU0337270200 | Lemanik Asset Management S.A. | 2,18% |
| UNI-GLOBAL EQUITIES WORLD - RA USD ACC | LU0929190568 | Lemanik Asset Management S.A. | 2,18% |
| UNI-GLOBAL EQUITIES WORLD - RAH EUR DIS H | LU0929190642 | Lemanik Asset Management S.A. | 2,18% |
| UNI-GLOBAL EQUITIES WORLD - AA USD ACC | LU1705548847 | Lemanik Asset Management S.A. | 2,18% |
| UNI-GLOBAL EQUITIES WORLD - IA USD ACC | LU1731102353 | Lemanik Asset Management S.A. | 2,18% |
| UNI-GLOBAL EQUITIES WORLD - AAC EUR ACC | LU1760480779 | Lemanik Asset Management S.A. | 2,18% |
| UNI-GLOBAL EQUITIES WORLD - ADH GBP ACC H | LU1819944361 | Lemanik Asset Management S.A. | 2,18% |
| FRANKLIN LIBERTYQ GLOBAL DIVIDEND UCITS ETF - USD DIS | IE00BF2B0M76 | Franklin Templeton International Services S.à r.l. | 2,12% |
| MULTIFAKTOR AKTIEN GLOBAL - P EUR DIS | LU1551351312 | LRI Invest S.A. | 1,93% |
| ROBECO QI GLOBAL VALUE EQUITIES - F EUR ACC | LU1001394219 | Robeco Luxembourg S.A. | 1,77% |
| ROBECO QI GLOBAL VALUE EQUITIES - Z EUR ACC | LU1058971620 | Robeco Luxembourg S.A. | 1,77% |
| XTRACKERS MSCI USA MINIMUM VOLATILITY UCITS ET - 1D USD DIS | IE00BDB7J586 | DWS Investment S.A. | 1,52% |
| BL GLOBAL FLEXIBLE EUR - A DIS | LU0211339816 | BLI - Banque de Luxembourg Investments S.A. | 1,51% |